The Lady Orc is a female version of the Orc melee enemy type. They are functionally identical to the Orc enemy and the only real difference is their visual. As such, they have thicc thighs and high health and are also considered to be a tank enemy.
You will need some good damage to take them down, as such, using defenses that have high damage outputs are recommended.
The Berserker Orcs found in Chaos 4 Expeditions and higher are commonly referred to as "Lady Orcs" by the community even though they are, in fact, completely different enemies.