Overview

Marks and Orbs both scale the same way like Medallions.

Marks and Orbs no longer drop.
Orbs were removed from the drop pool during the Ancient's Prelude patch (Update 1.2) and Marks were removed during Protean Shift Expansion (3.0)
Medallions, Marks, and Orbs are best to use on DPS and buffing defenses because it has more defense power than a totem.
Totems are best to use on Blockades because it has more defense health than Medallions, Marks, and Orbs.

Quality

Item Quality is represented by rarities shown below listed from the worst to the best.

All Stats Assume Max Upgrades (Minimum-Maximum stat rolls)
Medallions	Campaign	Chaos 1	Chaos 2	Chaos 3	Chaos 4	Chaos 5	Chaos 6	Chaos 7	Chaos 8	Chaos 9	Chaos 10
Defense Power	2,276~2,540	3,738~4,171	6,800~7,589	11,295~12,605	17,221~19,219	24,720~27,587	33,437~37,316	46,238~51,601	62,402~69,640	78,610~87,729	99,026~110,513
Defense Health	633~712	1,039~1,168	1,889~2,125	3,138~3,530	4,784~5,382	6,867~7,725	9,288~10,449	12,844~14,450	17,334~19,501	21,836~24,566	27,508~30,946
Tertiary - Crit Chance	0.3%-0.3%	0.4%-0.5%	0.6%-0.7%	1.1%-1.2%	1.6%-1.8%	2.3%-2.5%	3.1%-3.4%	4.2%-4.7%	5.6%-6.2%	7.1%-7.9%	9%-10%
Tertiary - Crit Damage	0.8%-0.8%	1.1%-1.4%	1.9%-2.2%	3.3%-3.5%	4.9%-5.5%	6.8%-7.6%	9.3%-10.1%	12.6%-14.2%	16.9%-18.8%	21.3%-23.8%	27%-30%
Tertiary - Defense Range	13-14	20-23	37-42	61-68	94-104	134-150	181-202	251-279	338-377	426-475	536-598
Tertiary - Defense Resist	0.3%-0.3%	0.4%-0.5%	0.6%-0.7%	1.1%-1.2%	1.6%-1.8%	2.3%-2.5%	3.1%-3.4%	4.2%-4.7%	5.6%-6.2%	7.1%-7.9%	9%-10%

All Stats Assume Max Upgrades (Minimum-Maximum stat rolls)
Totems	Campaign	Chaos 1	Chaos 2	Chaos 3	Chaos 4	Chaos 5	Chaos 6	Chaos 7	Chaos 8	Chaos 9	Chaos 10
Defense Health	1,518~1,694	2,492~2,781	4,534~5,060	7,530~8,403	11,481~12,813	16,480~18,392	22,292~24,877	30,825~34,401	41,601~46,427	52,407~58,486	66,018~73,676
Defense Power	949~1,067	1,558~1,752	2,834~3,188	4,706~5,295	7,176~8,073	10,300~11,588	13,932~15,674	19,266~21,674	26,001~29,251	32,754~36,849	41,261~46,419
Tertiary - Crit Chance	0.3%-0.3%	0.4%-0.5%	0.6%-0.7%	1.1%-1.2%	1.6%-1.8%	2.3%-2.5%	3.1%-3.4%	4.2%-4.7%	5.6%-6.2%	7.1%-7.9%	9%-10%
Tertiary - Crit Damage	0.8%-0.8%	1.1%-1.4%	1.9%-2.2%	3.3%-3.5%	4.9%-5.5%	6.8%-7.6%	9.3%-10.1%	12.6%-14.2%	16.9%-18.8%	21.3%-23.8%	27%-30%
Tertiary - Defense Range	13-14	20-23	37-42	61-68	94-104	134-150	181-202	251-279	338-377	426-475	536-598
Tertiary - Defense Resist	0.3%-0.3%	0.4%-0.5%	0.6%-0.7%	1.1%-1.2%	1.6%-1.8%	2.3%-2.5%	3.1%-3.4%	4.2%-4.7%	5.6%-6.2%	7.1%-7.9%	9%-10%