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Conventional wisdom dictates:<br/>
Defense Health (Mainstat on Totems) for walls (path blockers like barricade). <br/>
Defense Power (Mainstat on Medallion) for Towers and Auras as Mainstat so for example a Medallion. <br/>
Defense Critical Hit Chance is said to be capped around 33% chance so it's not needed much after you cap it with your ascension level points.